Prenatal hypoxia inhibited propionate‐evoked BK channels of mesenteric artery smooth muscle cells in offspring
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چکیده
منابع مشابه
Mechanism of Dopamine-mediated Activation of Bk Channels in Human Coronary Artery Smooth Muscle Cells
Coronary artery disease (CAD) is an important cause of morbidity and mortality worldwide and is associated with a sustained increase in vascular tone. Large conductance, voltage-dependent and calcium-activated potassium (K) channels, or BK channels determine membrane electrical activity in human coronary artery smooth muscle cells (HCASMCs). Their activation leads to hyperpolarization, a decrea...
متن کامل[Effect of IP3 on BK channels of porcine coronary artery smooth muscle cells].
D-myo-inositol 1,4,5-trisphosphate (IP(3)) plays an important role in signal transduction. It releases Ca(2+) from intracellular sites, which activates the Ca(2+)-dependent channels such as large-conductance Ca(2+)-activated potassium channels (BK channels). The present study was therefore designed to determine if the activity of BK channels in porcine coronary artery smooth muscle cells was in...
متن کاملSingle nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery.
Single smooth muscle cells were enzymatically isolated from the rabbit mesenteric artery. At physiological levels of external Ca, these cells were relaxed and contracted on exposure to norepinephrine, caffeine, or high levels of potassium. The patch-clamp technique was used to measure unitary currents through single channels in the isolated cells. Single channels were selective for divalent cat...
متن کاملTTX-sensitive voltage-gated Na+ channels are expressed in mesenteric artery smooth muscle cells.
The presence and properties of voltage-gated Na+ channels in mesenteric artery smooth muscle cells (SMCs) were studied using whole cell patch-clamp recording. SMCs from mouse and rat mesenteric arteries were enzymatically dissociated using two dissociation protocols with different enzyme combinations. Na+ and Ca2+ channel currents were present in myocytes isolated with collagenase and elastase....
متن کاملLong-term hypoxia increases calcium affinity of BK channels in ovine fetal and adult cerebral artery smooth muscle.
Acclimatization to high-altitude, long-term hypoxia (LTH) reportedly alters cerebral artery contraction-relaxation responses associated with changes in K(+) channel activity. We hypothesized that to maintain oxygenation during LTH, basilar arteries (BA) in the ovine adult and near-term fetus would show increased large-conductance Ca(2+) activated potassium (BK) channel activity. We measured BK ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2020
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.14994